Explore the must-sees at the bottom of the world with this Patagonia road trip itinerary

Snowy mountains behind meadows and a winding road — A road trip is a great way to see more of Patagonia | **kavram / Shutterstock**

Patagonia—a name that conjures images of jagged peaks, vast pampas, and turquoise lakes—is a destination for dreamers and adventurers. Straddling Chile and Argentina, this remote and untamed region offers an extraordinary variety of landscapes and experiences. While hiking Torres del Paine or marveling at the Perito Moreno Glacier might headline your journey, the beauty of Patagonia lies in the space between these iconic sights.

This is where the road trip comes in. Driving through Patagonia allows you to weave together its many wonders, from hidden estancias to penguin-dotted shores. Here, we offer a meticulously detailed two-week itinerary that balances must-see attractions with lesser-known gems, ensuring an immersive experience through this land of extremes.

Getting to Know Patagonia

A guanaco in front of snowy mountains — Guanaco inhabit the grassy hillsides of many remote areas in Patagonia | **Agnieszka Gaul / Shutterstock**

Patagonia is not a single landscape but a mosaic of environments that stretch across more than a million square kilometers of southern Chile and Argentina. It is defined by its dramatic contrasts—the towering peaks of the Andes rise above expansive steppe, while icy glaciers meet windswept grasslands. To the west lies Chilean Patagonia, with its fjords, dense forests, and temperate rainforests, while Argentine Patagonia to the east is characterized by arid plains and shimmering lakes.

The region’s weather is as dynamic as its scenery. Fierce winds and sudden rainstorms are common, but so too are moments of crystal-clear skies and brilliant sunshine. Locals often say you can experience all four seasons in a single day. Understanding Patagonia’s diverse geography and climate will help you prepare for its challenges and appreciate its many wonders.

Culturally, Patagonia is shaped by its history of indigenous peoples, European settlers, and gauchos (Patagonian cowboys). Visiting the region is an opportunity to learn about these cultural influences, from the Tehuelche people’s ancient rock art to the sheep-ranching traditions that persist on vast estancias. Whether hiking in a national park or savoring lamb roasted over an open fire, you’ll encounter the spirit of Patagonia at every turn.

Days 1–2: Punta Arenas, Chile’s Gateway to the South

Small buildings in front of mountains — The city of Punta Arenas is a great starting point for any Patagonia road trip | Ksenia Ragozina / Shutterstock

Your journey begins in Punta Arenas, a city perched on the Strait of Magellan. As one of the southernmost cities in the world, it serves as a vital entry point for explorers heading into Patagonia or beyond to Antarctica. While small, Punta Arenas is rich in history and offers an introduction to the region’s unique culture. It also has a well-served small airport and plenty of car hire options for road trippers.

Visit the Plaza Muñoz Gamero, surrounded by ornate mansions that echo the city’s prosperous sheep-ranching past. The nearby Museo Regional de Magallanes delves deeper into this history with exhibits on early settlers and indigenous cultures. Stroll along the waterfront, where you’ll find views of the Strait of Magellan—a reminder of Patagonia’s geographical isolation. Don’t miss the chance to sample fresh seafood at restaurants like La Marmita, which showcases local flavors with creative flair.

For practical matters, stock up on essentials before leaving Punta Arenas. Gas stations, grocery stores, and reliable Wi-Fi will be scarce once you hit the road. If you’re planning to camp, ensure you have high-quality gear to withstand Patagonia’s notoriously unpredictable weather.

Spend extra time exploring Punta Arenas’ unique landmarks, like the Cementerio Municipal, which features elaborately designed mausoleums reflecting the region’s multicultural history. If time permits, book a tour to Isla Magdalena to see its colony of Magellanic penguins. This day trip offers a glimpse into the region’s vibrant wildlife.

Days 3–5: Torres del Paine National Park

Drive 250 kilometers north to Puerto Natales, the gateway to Torres del Paine National Park. This charming town is worth a brief exploration—stop by Café Kaiken for a mate tea, and visit local artisans’ shops before continuing on. From Puerto Natales, it’s a short drive into the park itself, where the scenery begins to grow more dramatic with every kilometer.

Torres del Paine is often referred to as the crown jewel of Patagonia, and for good reason. Its dramatic peaks, glaciers, and wildlife-rich valleys create one of the world’s most stunning landscapes. For a three-day stay, you can mix day hikes with scenic drives to maximize your experience.

One unmissable hike is the trek to the Base of the Towers. This 18-kilometer round trip challenges even experienced hikers, but the payoff—standing beneath the park’s iconic granite spires—is unforgettable. For something less strenuous, the walk along Lago Grey provides access to viewpoints of Grey Glacier, or take a boat tour to see the glacier calving into the lake up close. Consider a guided kayak excursion on the lake for a unique vantage point.

Wildlife enthusiasts should explore the Laguna Azul area, where you’re likely to spot guanacos, foxes, and the majestic Andean condor. Early mornings are the best time for sightings, so plan accordingly.

Stay in one of the park’s refugios or nearby eco-lodges like Explora Torres del Paine. Alternatively, campsites like Paine Grande offer budget-friendly options for those prepared to rough it. Book early; accommodations within Torres del Paine fill months in advance.

Day 6: Crossing into Argentina

From Torres del Paine, head toward the Paso de Integración Austral border crossing to enter Argentina. The drive to El Calafate takes roughly five to six hours, including time for customs. Ensure your rental car includes cross-border permissions and carry all necessary paperwork, including proof of insurance. The drive itself is an experience, offering long stretches of unbroken pampas punctuated by glimpses of snow-capped mountains.

Along the way, make time for a stop at the remote village of Cerro Castillo. This small outpost offers a rustic charm and a chance to interact with locals who live on the fringes of Patagonia’s wilderness.

Days 7–8: El Calafate and the Perito Moreno Glacier

A gigantic glacier in a mountain valley — The Perito Moreno Glacier, Argentina | **Sangkhom Hungkhunthod / Shutterstock**

El Calafate, named after the calafate berry, serves as the gateway to Los Glaciares National Park. This bustling town caters to travelers but retains a relaxed charm. Use your first evening here to unwind after the drive and enjoy a hearty Argentine meal. Try La Tablita for excellent steak and Patagonian lamb.

Devote the next day to visiting the Perito Moreno Glacier, a 250-square-kilometer river of ice. While walkways provide excellent views of this advancing glacier, consider booking a guided trek across its surface for a more immersive experience. Walking with crampons on the glacier’s undulating ice fields is unforgettable. Don’t forget to take your time at the viewing platforms; the glacier’s calving process, where chunks of ice crash into the water, is one of Patagonia’s most awe-inspiring spectacles.

Take a boat tour across Lago Argentino for an alternative perspective of the glacier’s towering face. For those with more time, explore the lesser-visited Upsala and Spegazzini glaciers, which are equally breathtaking and less crowded.

Days 9–11: El Chaltén and the Fitz Roy Range

Snowy mountains behind golden meadows — Epic views abound throughout Patagonia | **LeeSensei / Shutterstock**

Continue north to El Chaltén, often referred to as the trekking capital of Argentina. As you approach, Mount Fitz Roy comes into view, its jagged peaks cutting an unmistakable silhouette against the sky. El Chaltén is a small, rustic village that serves as a base for hikers and climbers.

Spend your first afternoon exploring shorter trails like Mirador de los Condores for panoramic views of the valley. Over the next two days, tackle more challenging hikes. The Laguna de los Tres trail leads to a spectacular view of Fitz Roy reflected in an alpine lake. For a quieter, less-traveled route, opt for the Loma del Pliegue Tumbado trail, which offers sweeping vistas without the crowds.

Evenings in El Chaltén are about relaxation. The town’s brewery, La Cervecería, is the perfect spot to toast your day’s adventures with a locally crafted beer. If you’re staying longer, consider a guided climb of Fitz Roy itself, though it requires technical expertise and preparation.

Days 12–14: Return to Chile’s Lake District

A deep blue lake in front of mountains — Lake Lacar in Chile | **abriendomundo./ Shutterstock**

After leaving El Chaltén, consider an extended detour to explore Patagonia’s Lake District. Though farther north, this region’s emerald lakes, volcanic peaks, and lush forests offer a striking contrast to the stark beauty of the south. The Route of the Seven Lakes, which runs between San Martín de los Andes and Villa La Angostura, is particularly scenic and worth the additional driving time if you have a few extra days to spare.

Otherwise, begin the return journey to Punta Arenas. Overnight in Puerto Natales again to break up the drive. Here, take one last evening to reflect on your journey and enjoy the region’s fresh seafood offerings.

Tips for Hiring a Car in Patagonia

Renting the right vehicle is crucial for a successful Patagonian road trip. The region’s roads are as varied as its landscapes, ranging from smooth highways to rugged gravel paths known as "ripios." For most itineraries, a sturdy SUV or 4x4 is recommended. These vehicles handle gravel roads and high winds better than smaller cars, ensuring safety and comfort on longer drives.

Before booking, confirm that your rental agreement includes unlimited mileage—distances in Patagonia are vast. Additionally, ensure the rental agency allows cross-border travel if you plan to drive between Chile and Argentina. Companies like Europcar and Hertz often provide this option, but you’ll need additional insurance and paperwork.

When picking up your vehicle, inspect it thoroughly and document any pre-existing damage. Carry spare tires, a basic repair kit, and an extra fuel canister. Gas stations can be few and far between, especially on remote routes like Ruta 40 or the Carretera Austral. Planning ahead will save you from unnecessary stress.

Staying Safe When Driving

An orange jeep drives along a gravel road in Patagonia — Patagonia’s roads and weather offer challenging driving conditions | **kasakphoto / Shutterstock**

Driving in Patagonia comes with unique challenges, from unpredictable weather to the region’s infamous winds. Gusts can reach over 100 kilometers per hour, especially in open areas, so keep both hands on the wheel and reduce speed during strong winds.

Gravel roads (ripios) are common and can be slippery, particularly after rain. Drive slowly and avoid sudden braking to maintain control. When passing or being passed by another vehicle, stay as far to the side as possible to minimize the risk of flying gravel damaging your windshield.

Wildlife is another consideration. Guanacos, foxes, and even condors often wander onto roads. Drive cautiously, especially at dawn and dusk when animals are most active. If you encounter wildlife, slow down and give them plenty of space.

Lastly, always check road conditions before setting out. Websites like Ruta 0 provide up-to-date information on closures or hazards. Cell service is limited, so download maps and emergency contact numbers in advance.

What to Pack for a Patagonia Road Trip

A woman hikes across rocks — Outdoor clothing is essential in Patagonia, regardless of the time of year | **sharptoyou / Shutterstock**

Packing wisely can make or break your Patagonian adventure. The region’s weather is famously unpredictable, so layers are essential. Bring a waterproof jacket, warm fleece, and quick-drying base layers. Sturdy hiking boots are a must, as even short walks often involve uneven terrain.

Other essentials include a good-quality map or GPS device, a first-aid kit, and plenty of snacks and water. For camping, invest in a four-season tent and a high-rated sleeping bag to withstand cold nights. A portable stove and cooking supplies will make remote overnights more comfortable.

Don’t forget smaller items like sunscreen, sunglasses, and insect repellent. Patagonia’s sun can be intense, and while bugs are less common, they can be a nuisance in certain areas. Finally, carry a reusable water bottle or hydration system. Glacial streams provide some of the purest water you’ll ever taste, and staying hydrated is key to enjoying long days on the road.

Final Thoughts: Lessons from Patagonia’s Wild Roads

A road trip through Patagonia is about more than just reaching iconic destinations. It’s about the moments in between: spotting a solitary guanaco grazing on the steppe, sipping mate by a windswept lake, and feeling the humbling power of nature at its most untamed. To make the most of this journey, embrace flexibility. Patagonia’s weather is unpredictable, and road conditions can be challenging, but every twist and turn reveals a landscape that feels both ancient and alive.